客观的。与旧世界非人类灵长类 (NHP) 物种相比,普通狨猴由于其体型更小、更易于处理和繁殖更快,因此越来越多地用于神经接口研究。虽然对狨猴皮层解剖结构的评估显示出与猕猴惊人相似的布局,但不存在对该桥物种前肢到达运动的电生理特性的综合评估。本研究的目的是表征从狨猴初级运动皮层 (M1) 在伸手任务期间记录的信号的电生理特性,并与较大的 NHP 模型进行比较,以便这种较小的 NHP 模型可用于行为神经接口研究。方法和主要结果。在三只成年雄性狨猴的 M1 中长期记录神经元放电率和局部场电位 (LFP)。对 LFP 的发射率、mu + beta 和高伽马频带进行了评估,以了解关于运动的调制。狨猴 M1 神经元的放电率和规律性与猕猴中报告的相似,其中一组神经元显示出对运动方向的选择性。运动阶段(休息与运动)分为神经尖峰和 LFP。微电极阵列提供了对运动皮层的小区域进行采样以驱动脑机接口 (BMI) 的能力。结果表明,狨猴是行为神经科学研究的强大桥梁物种,其运动皮层电生理信号是从类似于旧世界 NHP 的微电极阵列记录的。意义。由于狨猴代表了啮齿动物和猕猴模型之间有趣的一步,成功证明狨猴运动皮层中的神经元调制类似于猕猴中的报告说明了狨猴作为 BMI 研究的可行物种的实用性。
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Chronic recordings from the marmoset motor cortex reveals modulation of neural firing and local field potentials overlap with macaques
Objective. The common marmoset has been increasingly used in neural interfacing studies due to its smaller size, easier handling, and faster breeding compared to Old World non-human primate (NHP) species. While assessment of cortical anatomy in marmosets has shown strikingly similar layout to macaques, comprehensive assessment of electrophysiological properties underlying forelimb reaching movements in this bridge species does not exist. The objective of this study is to characterize electrophysiological properties of signals recorded from the marmoset primary motor cortex (M1) during a reach task and compare with larger NHP models such that this smaller NHP model can be used in behavioral neural interfacing studies. Approach and main results. Neuronal firing rates and local field potentials (LFPs) were chronically recorded from M1 in three adult, male marmosets. Firing rates, mu + beta and high gamma frequency bands of LFPs were evaluated for modulation with respect to movement. Firing rate and regularity of neurons of the marmoset M1 were similar to that reported in macaques with a subset of neurons showing selectivity to movement direction. Movement phases (rest vs move) was classified from both neural spiking and LFPs. Microelectrode arrays provide the ability to sample small regions of the motor cortex to drive brain–machine interfaces (BMIs). The results demonstrate that marmosets are a robust bridge species for behavioral neuroscience studies with motor cortical electrophysiological signals recorded from microelectrode arrays that are similar to Old World NHPs. Significance. As marmosets represent an interesting step between rodent and macaque models, successful demonstration that neuron modulation in marmoset motor cortex is analogous to reports in macaques illustrates the utility of marmosets as a viable species for BMI studies.